Understanding early heart function issues in hypertrophic cardiomyopathy
Official title: Early Onset Diastolic Dysfunction in HCM: Identifying New Mechanisms and Targets
Funded at University of Arizona · NIH-11045937 · Data updated 2026-11-12
This study is looking at how heart problems can start early in people with hypertrophic cardiomyopathy (HCM) and aims to find new ways to help those who have the genetic markers for this condition before they feel any serious symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $618,045 |
| NIH project number | 1R01HL172871-01A1 |
| Project ID | NIH-11045937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to hypertrophic cardiomyopathy, particularly those who are genotype-positive but phenotype-negative.
✕Less likely to help
Patients who do not have genetic mutations associated with hypertrophic cardiomyopathy or those with advanced symptoms may not benefit from this research.
What this research studies
This research investigates the early onset of diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), a common genetic heart condition. By identifying the mechanisms behind this dysfunction, the study aims to find new treatment targets that could help patients before they experience severe symptoms. The approach includes analyzing genetic mutations and their effects on heart muscle function, potentially using advanced imaging and computational models. The goal is to intervene early in patients who carry genetic markers for HCM but do not yet show symptoms.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more effective treatments for patients with hypertrophic cardiomyopathy, improving their quality of life and reducing the risk of severe complications.
How similar studies have gone: Previous research has shown promise in identifying early mechanisms of heart dysfunction in similar genetic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Tardiff, Jil C — University of Arizona
- Study coordinator: Tardiff, Jil C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.