Understanding early cognitive problems in Parkinson's patients
Official title: Investigating the Neurobiology of Early Cognitive Impairment
Funded at Icahn School of Medicine at Mount Sinai · NIH-11019817 · Data updated 2026-11-12
This study is looking into how early thinking problems can start in people with Parkinson's, even before they show any movement issues, especially in those with certain genetic traits, to help find ways to slow down or prevent these cognitive challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $717,056 |
| NIH project number | 5R01NS135728-02 |
| Project ID | NIH-11019817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with early-stage Parkinson's disease, particularly those with genetic mutations associated with cognitive decline.
✕Less likely to help
Patients with advanced Parkinson's disease or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the neurobiology behind early cognitive impairment in Parkinson's patients, particularly during a phase when motor symptoms are not yet present. It focuses on understanding how cognitive deficits, such as attention issues and slower information processing, develop in individuals with specific genetic mutations linked to Parkinson's. By using a mouse model with a gene mutation that increases the risk of cognitive decline, the study aims to uncover the biological mechanisms at play, which could lead to targeted therapies to slow or prevent further cognitive deterioration.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve cognitive function in Parkinson's patients, improving their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding cognitive impairment in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Huntley, George W. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Huntley, George W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.