Understanding early changes in breast tissues of women at high risk for cancer
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-10977480
This study is looking at breast tissue from women with genetic mutations that increase their risk of breast cancer to find early signs of changes that could lead to cancer, helping us learn how to catch and prevent the disease sooner.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10977480 on ClinicalTrials.gov |
What this research studies
This research focuses on analyzing breast tissues from women who carry genetic mutations linked to a higher risk of developing breast cancer. By utilizing advanced technologies such as mass cytometry, single cell RNA sequencing, and multiplex imaging, the study aims to identify early premalignant changes in these tissues. This approach allows researchers to detect subtle differences in cell populations that could indicate the onset of cancer, providing insights into how breast cancer develops in high-risk individuals. The ultimate goal is to develop strategies for early detection and prevention of breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who carry BRCA1 or BRCA2 mutations and are at high risk for developing breast cancer.
Not a fit: Patients without BRCA mutations or those who do not have a family history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and prevention of breast cancer in high-risk women.
How similar studies have performed: Previous research has shown promise in using similar single-cell analysis techniques to understand cancer development, indicating a potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRUGGE, JOAN SIEFERT — HARVARD MEDICAL SCHOOL
- Study coordinator: BRUGGE, JOAN SIEFERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.