Understanding early changes in breast tissue for women at high risk of cancer
Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development
['FUNDING_OTHER'] · HARVARD MEDICAL SCHOOL · NIH-10895320
This study is looking at how breast tissue changes in women with certain genetic mutations that increase their risk of breast cancer, using cutting-edge technology to find early signs of cancer, so we can help with early detection and prevention for those at higher risk.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10895320 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying early changes in breast tissues from women who carry genetic mutations linked to a higher risk of developing breast cancer. By using advanced technologies such as mass cytometry and single-cell RNA sequencing, the study aims to analyze individual breast cells to uncover distinct cell populations that may indicate a progression towards cancer. The goal is to develop strategies for early detection and prevention of breast cancer in these high-risk individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who carry BRCA1 or BRCA2 mutations and are at high risk for breast cancer.
Not a fit: Patients who do not carry BRCA1 or BRCA2 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and prevention of breast cancer in women with genetic predispositions.
How similar studies have performed: Other research has shown promise in using single-cell analyses to understand cancer progression, indicating that this approach may yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRUGGE, JOAN SIEFERT — HARVARD MEDICAL SCHOOL
- Study coordinator: BRUGGE, JOAN SIEFERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.