Understanding dysautonomia after infections like COVID-19 and Lyme disease
Official title: Post-Infectious Dysautonomia: Insights into Clinical Phenotypes and Disease Pathogenesis
Funded at Johns Hopkins University · NIH-11054939 · Data updated 2026-11-12
This study is looking at dysautonomia, a condition that can happen after infections like COVID-19 and Lyme disease, to better understand its symptoms and causes, especially how the immune system might be involved, and it’s for patients who are experiencing these issues to help find new treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $198,720 |
| NIH project number | 1K23AI180356-01A1 |
| Project ID | NIH-11054939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced dysautonomia symptoms after COVID-19 or Lyme disease.
✕Less likely to help
Patients who have not experienced dysautonomia or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates dysautonomia, a condition affecting the autonomic nervous system that can occur after infections such as COVID-19 and Lyme disease. It aims to identify the clinical features and underlying mechanisms of this condition, particularly focusing on the role of autoantibodies and nerve damage. Patients with post-infectious dysautonomia will undergo various tests to assess their autonomic function and nerve health, helping to uncover potential treatment options. The study will utilize resources from specialized clinics to ensure comprehensive patient evaluation.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from dysautonomia following infections.
How similar studies have gone: Previous research has shown promising results in understanding dysautonomia and its treatment, particularly in patients with autoimmune components, suggesting this approach has potential.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Adler, Brittany Lee — Johns Hopkins University
- Study coordinator: Adler, Brittany Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.