Understanding drug resistance in tuberculosis infections
Undetected Drug resistance and Tolerance in lesions of recurrent TB
This study is looking into why some tuberculosis bacteria can stick around and make people sick even after treatment, and it’s for patients who are having surgery for TB, as their samples will help find better ways to diagnose and treat these tough bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10879125 on NIH RePORTER |
What this research studies
This research investigates the reasons why tuberculosis (TB) bacteria can survive treatment and cause ongoing illness in patients. By examining the genetic and epigenetic makeup of the bacteria directly from lung lesions, the study aims to identify undetected resistant strains and understand how these bacteria evade standard diagnostics. The findings could lead to the development of more effective diagnostic tools and treatments that specifically target these resilient bacteria. Patients undergoing surgical treatment for TB may provide critical samples for this research.
Who could benefit from this research
Good fit: Ideal candidates for participation are patients with recurrent tuberculosis who require surgical intervention.
Not a fit: Patients with non-recurrent tuberculosis or those who have not undergone surgical treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and therapies for tuberculosis, ultimately reducing the burden of this disease.
How similar studies have performed: Previous research has shown promise in understanding drug resistance in tuberculosis, but this approach is innovative in its focus on the genomic analysis of bacteria directly from lesions.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Valafar, Faramarz — San Diego State University
- Study coordinator: Valafar, Faramarz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.