Understanding Down syndrome and its effects across the lifespan
Official title: Human Trisome Project - Latin America Network
Funded at University of Colorado Denver · NIH-11001722 · Data updated 2026-11-12
This study is looking at how Down syndrome affects growth, learning, and aging in people with the condition, and it aims to find out what influences their health, so we can better support individuals with Down syndrome around the world.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,693,143 |
| NIH project number | 1U01HD116469-01 |
| Project ID | NIH-11001722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals with Down syndrome of all ages, particularly those with trisomy 21.
✕Less likely to help
Patients without Down syndrome or those who do not have a genetic condition related to trisomy 21 may not benefit from this research.
What this research studies
This research investigates the unique clinical profile of individuals with Down syndrome (DS) caused by trisomy 21, focusing on their growth, neurodevelopmental delays, and accelerated aging. It aims to explore the mechanisms behind these conditions and the factors that influence health outcomes in this population. The study includes a natural history component, collecting extensive clinical data, cognitive assessments, and biological samples to better understand the health challenges faced by individuals with DS. By expanding the research to include diverse populations globally, the project seeks to enhance the understanding of DS and improve care strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes and tailored interventions for individuals with Down syndrome.
How similar studies have gone: Previous studies on Down syndrome have shown promise in understanding its complexities, but this international approach is novel and aims to fill existing gaps.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Espinosa, Joaquin M. — University of Colorado Denver
- Study coordinator: Espinosa, Joaquin M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.