Understanding dormant cells in aggressive brain tumors
Defining cellular states of quiescence in human brain tumors
['FUNDING_R01'] · FRED HUTCHINSON CANCER CENTER · NIH-11004954
This study is looking at the sleepy cells in glioblastoma, a tough type of brain tumor, to see how they help the tumor grow and resist treatments like chemotherapy and radiation, with the hope of finding better ways to stop the tumor from coming back and helping patients feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11004954 on ClinicalTrials.gov |
What this research studies
This research investigates the quiescent or dormant cells found in glioblastoma, the most aggressive type of brain tumor. By analyzing these cells, the study aims to understand how they contribute to tumor growth and resistance to standard treatments like chemotherapy and radiation. The researchers will use advanced techniques, including single-cell genomic analysis, to define the molecular characteristics of these dormant cells and their responses to therapy. This knowledge could lead to new strategies for preventing tumor recurrence and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing standard treatment.
Not a fit: Patients with other types of brain tumors or those who are not currently receiving treatment for glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates and reducing tumor recurrence.
How similar studies have performed: Other research has shown promise in targeting dormant cancer cells, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PADDISON, PATRICK — FRED HUTCHINSON CANCER CENTER
- Study coordinator: PADDISON, PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Genes, cancer metastasis