Understanding dopamine receptor changes in OCD and tic disorders
Dysregulation of dopamine receptors in the basal ganglia in OCD and tic disorders: Positron Emission Tomography with [11C]-PHNO
This study is looking at how certain brain receptors related to dopamine work differently in people with obsessive-compulsive disorder and tic disorders like Tourette syndrome, using special imaging to help find better ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11088268 on NIH RePORTER |
What this research studies
This research investigates how dopamine receptors in the brain are altered in individuals with obsessive-compulsive disorder (OCD) and tic disorders like Tourette syndrome. Using advanced imaging techniques, specifically Positron Emission Tomography (PET) with a tracer called [11C]-PHNO, the study aims to identify patterns of receptor dysregulation in the basal ganglia, a brain region involved in movement and behavior. By examining both genetic and non-genetic forms of these disorders, the research seeks to uncover the underlying biological mechanisms that contribute to symptoms, potentially leading to improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with obsessive-compulsive disorder or tic disorders, particularly those with a genetic predisposition.
Not a fit: Patients with unrelated neuropsychiatric conditions or those without a diagnosis of OCD or tic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for patients suffering from OCD and tic disorders.
How similar studies have performed: Previous research has shown promising results in understanding dopamine dysregulation in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Pittenger, Christopher John — Yale University
- Study coordinator: Pittenger, Christopher John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.