Understanding DNA replication and damage in gliomas with IDH mutations
Official title: Analyzing DNA replication and damage vulnerability in IDH mutant glioma
Funded at Massachusetts General Hospital · NIH-11045750 · Data updated 2026-11-12
This study is looking at how certain brain tumors with a specific gene change respond to treatments and is exploring new ways to make those treatments work better and with fewer side effects, aiming to help patients with these challenging tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $401,140 |
| NIH project number | 5R01CA289485-02 |
| Project ID | NIH-11045750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with IDH mutant gliomas who have not responded well to standard therapies.
✕Less likely to help
Patients with gliomas that do not have IDH mutations may not benefit from this research.
What this research studies
This research investigates how gliomas with mutations in the IDH1 enzyme respond to current therapies and explores new treatment strategies. The team aims to understand the unique metabolic vulnerabilities of these tumors and how they can be targeted more effectively. By examining the role of specific enzymes involved in DNA repair and replication stress, the researchers hope to develop therapies that minimize side effects while maximizing cancer cell destruction. This work could lead to improved treatment options for patients with these aggressive brain tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic treatments for patients with IDH mutant gliomas.
How similar studies have gone: Previous research has shown promising results in targeting metabolic vulnerabilities in similar types of tumors, suggesting potential for success in this approach.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Cahill, Daniel P. — Massachusetts General Hospital
- Study coordinator: Cahill, Daniel P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.