Understanding DNA repair in early lung cancer development
Characterization of DNA repair in genomic and transcriptomic evolution of early lung carcinogenesis
['FUNDING_OTHER'] · RLR VA MEDICAL CENTER · NIH-10881734
This study is looking at how our body's DNA repair processes might play a role in the early development of lung cancer, especially in people at high risk, to help find better ways to diagnose and treat it sooner.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RLR VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10881734 on ClinicalTrials.gov |
What this research studies
This research investigates how DNA repair mechanisms contribute to the evolution of lung cancer, particularly in early stages. It focuses on identifying pre-malignant lesions and understanding their transition to malignant forms, which is crucial for timely diagnosis and treatment. The study aims to improve diagnostic methods and therapeutic targets for early non-small cell lung cancers, potentially leading to better patient outcomes. By analyzing genomic changes, the research seeks to provide insights that could enhance screening strategies for high-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for lung cancer, such as veterans and those with pre-malignant lung lesions.
Not a fit: Patients with advanced-stage lung cancer or those without any risk factors for lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of lung cancer, improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in understanding DNA repair mechanisms in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- RLR VA MEDICAL CENTER — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEARS, CATHERINE RUFATTO — RLR VA MEDICAL CENTER
- Study coordinator: SEARS, CATHERINE RUFATTO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause