Understanding DNA Repair in Cancer Using Yeast
Enzymology of Mismatch Repair in Yeast
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11110383
This research explores how cells fix mistakes in their DNA, using baker's yeast as a model to learn more about how these processes work in human cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11110383 on ClinicalTrials.gov |
What this research studies
Our cells have special repair systems, called DNA mismatch repair (MMR), that fix errors in our genetic code. When these systems don't work correctly, it can lead to an increased risk of cancer and make some cancer treatments less effective. This project uses yeast, a simple organism, to carefully examine the exact steps and molecules involved in these crucial DNA repair processes. By understanding these fundamental mechanisms in yeast, we can gain insights into how similar repair systems function in human cells and how their malfunction contributes to cancer development and treatment resistance.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals with cancers linked to DNA mismatch repair defects.
Not a fit: Patients whose cancers are not related to DNA mismatch repair pathways may not directly benefit from this specific line of basic research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of why some cancers develop and how they respond to treatments, potentially guiding the development of new therapies for MMR-deficient cancers.
How similar studies have performed: The fundamental principles of DNA mismatch repair are well-established, and this research builds upon decades of successful studies using model organisms to understand conserved biological processes.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOLODNER, RICHARD D — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: KOLODNER, RICHARD D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Treatment, Cancers