Understanding DNA Repair in Cancer and Other Diseases
Integrating Genomic Signatures with Functional Analysis of DNA repair
['FUNDING_R21'] · BROAD INSTITUTE, INC. · NIH-11135359
This work aims to create new tools to better understand how DNA repair works in human cells, which is important for conditions like cancer, aging, and neurodegeneration.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROAD INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11135359 on ClinicalTrials.gov |
What this research studies
Our bodies rely on DNA repair to fix damage and prevent diseases like cancer, premature aging, and immune problems. When DNA repair doesn't work well, it can lead to harmful changes and illness. This project is developing advanced ways to measure how well all the major DNA repair pathways are working in individual human cells. By creating these new high-throughput tools, we hope to get a clearer picture of DNA repair's role in protecting against disease.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals affected by diseases linked to genome instability, such as various cancers, premature aging, neurodegeneration, and immunodeficiency.
Not a fit: Patients whose conditions are not related to DNA repair mechanisms or genome instability may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how DNA repair contributes to various diseases, potentially guiding the development of new treatments for cancer, aging-related conditions, and neurodegenerative disorders.
How similar studies have performed: While mutational signatures offer some insights, direct, large-scale functional measurements of DNA repair at single-cell resolution are a novel and currently unavailable approach.
Where this research is happening
CAMBRIDGE, UNITED STATES
- BROAD INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAGEL, ZACHARY DAVID — BROAD INSTITUTE, INC.
- Study coordinator: NAGEL, ZACHARY DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer cell line, Cancers