Understanding DNA Repair and Colorectal Cancer
DNA Damage Repair by MUTYH and MUTYH Variants Associated with Colorectal Cancer
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11109409
This work explores how a specific DNA repair protein, MUTYH, works and how its changes can lead to an inherited form of colorectal cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11109409 on ClinicalTrials.gov |
What this research studies
Our bodies have a natural defense system to fix damaged DNA, and a protein called MUTYH is a key player in this process. When MUTYH doesn't work correctly due to inherited changes, it can increase the risk of developing colorectal cancer, a condition known as MUTYH-associated polyposis (MAP). This project aims to uncover the detailed ways MUTYH recognizes and repairs DNA damage, especially focusing on how specific changes in the MUTYH protein affect its ability to protect against cancer. By combining detailed lab tests with studies in cells, we are learning more about how these defects contribute to cancer development. This deeper understanding helps us connect MUTYH's function to the risk of cancer.
Who could benefit from this research
Good fit: This foundational research is most relevant to individuals with MUTYH-associated polyposis or those with a family history of colorectal cancer linked to MUTYH gene changes.
Not a fit: Patients whose colorectal cancer is not linked to MUTYH gene mutations may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of colorectal cancer development, potentially guiding future strategies for prevention, early detection, or targeted treatments for individuals with MUTYH-associated polyposis.
How similar studies have performed: Our laboratory previously provided key enzymatic analysis that helped establish the connection between MUTYH variants and colorectal cancer, building on existing knowledge in the field.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVID, SHEILA SUE — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: DAVID, SHEILA SUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.