Understanding DNA Ligase 1 in Huntington's Disease
Dissecting the role of DNA Ligase 1 in Huntington's disease
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11113924
This work explores how a specific gene, DNA Ligase 1, affects the progression of Huntington's disease to find new ways to help patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11113924 on ClinicalTrials.gov |
What this research studies
Huntington's disease is a severe condition caused by a genetic change that gets worse over time. We know that certain genes involved in DNA repair, like DNA Ligase 1, can influence when symptoms start. This project aims to understand how different versions of the DNA Ligase 1 gene either speed up or slow down the disease. By studying these genetic differences, we hope to uncover the exact ways they impact the disease process and cellular health. This knowledge could lead to new strategies for treatment.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the genetic mechanisms of Huntington's disease.
Not a fit: Patients not diagnosed with Huntington's disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new targets for therapies that might delay the onset or slow the progression of Huntington's disease.
How similar studies have performed: While the specific role of DNA Ligase 1 in Huntington's disease is being newly explored in this context, genome-wide association studies have previously identified DNA repair genes as modifiers of disease onset.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHEELER, VANESSA C — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: WHEELER, VANESSA C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.