Understanding DNA damage and repair to improve disease prevention
Measuring genomic DNA damage and DNA repair capacity in longitudinal population samples - a step towards precision prevention
This study is looking at how well your body can fix damage to your DNA and how that might help us find better ways to prevent diseases, especially for people who might be at higher risk based on their genetic makeup.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10817292 on NIH RePORTER |
What this research studies
This research investigates how genomic DNA damage and the body's ability to repair this damage can inform personalized prevention strategies for diseases. By analyzing population samples over time, the study aims to identify individuals at higher risk for diseases based on their DNA repair capacity. Advanced technologies will be used to assess various molecular markers, which could lead to targeted screening and early interventions to reduce disease susceptibility. The goal is to enhance our understanding of how genetic factors contribute to health outcomes and to develop tailored prevention approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or other diseases linked to DNA repair deficiencies.
Not a fit: Patients with no known genetic predisposition to diseases or those who are not interested in genetic testing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized prevention strategies that significantly reduce the risk of diseases, particularly cancer.
How similar studies have performed: Other research has shown promise in using genomic analysis for personalized medicine, indicating that this approach could be effective.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Sobol, Robert W — Brown University
- Study coordinator: Sobol, Robert W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.