Understanding DNA Changes in Our Cells
Mechanistic Insights into Mammalian DNA Methylation
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA RIVERSIDE · NIH-11088244
This research helps us understand how natural changes in our DNA, called methylation, work and how problems with these changes can lead to diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA RIVERSIDE (nih funded) |
| Locations | 1 site (RIVERSIDE, UNITED STATES) |
| Trial ID | NIH-11088244 on ClinicalTrials.gov |
What this research studies
Our bodies have a natural process called DNA methylation, which is like a switch that turns genes on or off, and it's vital for healthy cell function. When this process goes wrong, it can cause instability in our genetic material and silence important genes that protect us from diseases, such as tumor suppressor genes. This can contribute to the development of cancers and other health problems. This project aims to uncover the detailed ways these DNA changes are controlled in our cells, especially focusing on the proteins that establish and maintain them. By learning more about these fundamental processes, we hope to find new ways to address diseases linked to faulty DNA methylation.
Who could benefit from this research
Good fit: This basic science research does not involve patient participation, but its future findings could eventually benefit patients with various cancers and other conditions linked to DNA methylation errors.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from participating in this foundational laboratory research.
Why it matters
Potential benefit: If successful, this foundational knowledge could lead to new strategies for preventing or treating cancers and other human diseases caused by abnormal DNA methylation.
How similar studies have performed: While the specific mechanisms are still being uncovered, previous research has established the critical role of DNA methylation in health and disease, providing a strong foundation for this work.
Where this research is happening
RIVERSIDE, UNITED STATES
- UNIVERSITY OF CALIFORNIA RIVERSIDE — RIVERSIDE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SONG, JIKUI — UNIVERSITY OF CALIFORNIA RIVERSIDE
- Study coordinator: SONG, JIKUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Suppressor Genes, Cancers