Understanding DNA Changes in Human Diseases and Evolution at a Single-Cell Level
Single-Cell Analysis of the Noncoding Genome in Human Diseases and Evolution
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11132667
This work explores how tiny changes in our DNA, especially in areas that don't code for proteins, contribute to human health conditions and how we've evolved from chimpanzees.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11132667 on ClinicalTrials.gov |
What this research studies
Our bodies are made of many different types of cells, and each cell's DNA plays a role in how it functions. This project looks closely at the parts of our DNA that don't directly make proteins but still control how our genes work. By examining these noncoding DNA changes in individual cells, we hope to learn how they lead to diseases or influence human traits. We are developing new computer tools to help us find these important changes and understand their effects on specific cell types.
Who could benefit from this research
Good fit: This foundational work is not recruiting patients directly but aims to benefit individuals with various human diseases by uncovering their genetic origins.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could help us pinpoint the exact DNA changes that cause human diseases, potentially leading to new ways to prevent or treat them.
How similar studies have performed: The research builds on recent successes in analyzing disease genomes and identifying key elements of human evolution, using innovative approaches.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, JINGJING — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: LI, JINGJING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.