Understanding DNA Changes in Early Life
DNA Methylation Dynamics of Mammalian Development
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11144429
This project aims to map how DNA changes guide the development of different cell types in early life, which can help us understand developmental conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11144429 on ClinicalTrials.gov |
What this research studies
Our bodies start from a few basic cells that then transform into all the different cell types we have. This transformation is guided by special instructions on our DNA, called epigenetics, which tell genes when to turn on or off. We are particularly interested in a key instruction called DNA methylation, which acts like a gatekeeper for gene activity. By creating a detailed map of these DNA changes during development, we hope to better understand how cells commit to their specific roles. This knowledge is crucial because unusual DNA methylation patterns are linked to many developmental disorders and diseases.
Who could benefit from this research
Good fit: Patients with developmental disorders or those interested in the basic biological mechanisms underlying human development might find this research relevant.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this foundational basic science project.
Why it matters
Potential benefit: If successful, this work could provide a fundamental understanding of how developmental disorders arise, potentially leading to new ways to identify or address these conditions in the future.
How similar studies have performed: While single-cell studies of RNA are common, creating a detailed atlas of DNA methylation at this resolution is a novel approach made possible by new technologies developed by this team.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ADEY, ANDREW — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: ADEY, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.