Understanding DNA Changes in Cancer and Other Conditions
Computational methods for detecting patterns of complex genomic variation
This project is creating advanced computer tools to better understand complex changes in our DNA that are linked to conditions like cancer and inherited diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11158969 on NIH RePORTER |
What this research studies
Our bodies' cells can have changes in their DNA, called structural variations, which can lead to serious health problems like cancer or genetic conditions. This project aims to build new computer programs and methods to map out these complex DNA changes more clearly. By using advanced sequencing technologies and computational approaches, we hope to get a more complete picture of how these DNA rearrangements affect our health. This improved understanding could help us better identify and characterize these conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit patients with cancers or constitutional genetic disorders by improving diagnostic and prognostic tools.
Not a fit: Patients not affected by complex genomic variations or those seeking immediate treatment options would not directly benefit from this foundational computational work.
Why it matters
Potential benefit: If successful, this work could lead to more accurate ways to detect and understand the specific DNA changes that cause or worsen diseases like cancer and inherited conditions.
How similar studies have performed: This is a renewal proposal that builds upon previous work, developing novel computational methods and applying them to new sequencing technologies to advance the field.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Bafna, Vineet — University of California, San Diego
- Study coordinator: Bafna, Vineet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.