Understanding DNA Changes in Cancer
Establishing and Interpreting Abnormal DNA Methylation in Cancer
This work helps us understand how changes in DNA, specifically a protein called DNMT3A, contribute to the development of various cancers, including leukemia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-11132685 on NIH RePORTER |
What this research studies
Our bodies have a protein called DNMT3A that is important for brain development and blood cell formation. When this protein has mutations, it can lead to conditions like leukemia and other cancers. We are looking closely at how DNMT3A works inside cells, especially how it interacts with the DNA packaging structures called nucleosomes. This includes studying a specific form of DNMT3A that is often found in solid tumors. By using advanced techniques and models, we aim to uncover how these DNA changes happen and contribute to cancer.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the biological mechanisms relevant to individuals with various cancers, particularly those with mutations in the DNMT3A gene or related conditions like leukemia.
Not a fit: Patients whose cancers do not involve DNA methylation anomalies or the specific DNMT3A protein may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to detect, prevent, or treat cancers by targeting the specific DNA changes involved.
How similar studies have performed: While the general concept of DNA methylation in cancer is known, this approach uses new insights and a novel understanding of how DNMT3A interacts with DNA packaging, making it a unique and promising direction.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Jones, Peter a — Van Andel Research Institute
- Study coordinator: Jones, Peter a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.