Understanding DNA changes in cancer
Investigation of human DNA polymerase epsilon variants
This work explores how certain DNA changes, especially in genes like BRCA2, contribute to the development of highly mutated cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11119022 on NIH RePORTER |
What this research studies
We want to understand why some cancers have many DNA changes and how cells fail to protect themselves from these changes. Our focus is on specific DNA replication enzymes called POLE, which are often mutated in highly aggressive tumors. We believe that problems with POLE, combined with issues in other DNA repair genes like BRCA2, lead to unstable DNA and cancer growth. By studying these mechanisms, we hope to uncover new ways to fight these challenging cancers.
Who could benefit from this research
Good fit: This foundational research is most relevant to patients with cancers characterized by specific DNA polymerase mutations or those with BRCA2 mutations, as it aims to understand the underlying biology of their disease.
Not a fit: Patients whose cancers do not involve these specific DNA polymerase mutations or related DNA repair pathway issues may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how certain cancers develop, potentially guiding the creation of new treatments for patients with highly mutated tumors, including those with BRCA2 mutations.
How similar studies have performed: This project builds upon the researchers' own published work and preliminary data, suggesting a foundation of prior findings in this area.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Pursell, Zachary F — Tulane University of Louisiana
- Study coordinator: Pursell, Zachary F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.