Understanding Discogenic Low Back Pain
Studying the mechanism of discogenic low back pain induction.
This project aims to discover why some degenerative spinal discs cause pain in adults, hoping to find new ways to help people with chronic low back pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11092836 on NIH RePORTER |
What this research studies
Many adults experience low back pain due to changes in their spinal discs, but it's not always clear why some discs become painful while others don't. Our goal is to create a human-based model to understand the exact reasons behind this discogenic pain. We will use advanced techniques, including studying human disc tissues and specialized cells, to identify the specific cells and processes that lead to pain. By understanding these mechanisms, we hope to find new targets for treatments that go beyond just managing symptoms.
Who could benefit from this research
Good fit: This research is relevant to adults aged 21 and older who experience low back pain specifically caused by degenerative spinal discs.
Not a fit: Patients whose low back pain is not related to intervertebral disc degeneration may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that address the root cause of discogenic low back pain, offering more effective and lasting relief for patients.
How similar studies have performed: This project builds upon previous successful studies where researchers established methods to simulate disc degeneration and sense pain signals in laboratory settings.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Sheyn, Dmitriy — Cedars-Sinai Medical Center
- Study coordinator: Sheyn, Dmitriy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.