Understanding Difficult Labor in Pregnancy
Biologic Mechanisms of Labor Dysfunction: A Systems Biology Approach
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11089309
This project aims to understand why some pregnant individuals experience difficult labor, especially those with higher body mass index.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11089309 on ClinicalTrials.gov |
What this research studies
Maternal mortality is a growing concern, and difficult labor is a major reason for complications, particularly for individuals with higher BMI. This often leads to unplanned C-sections because labor doesn't start or progress as expected. Researchers believe that too much fat in certain tissues might weaken uterine contractions. This project will recruit pregnant individuals to study how changes in their body's fats throughout pregnancy might predict difficult labor.
Who could benefit from this research
Good fit: Ideal candidates are individuals in early pregnancy who plan to give birth in a community-based care setting.
Not a fit: Patients who are not pregnant or are not experiencing labor complications would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to predict and prevent difficult labor, improving safety for both mothers and babies.
How similar studies have performed: While current research suggests a link between metabolism and labor, this project aims to fill existing knowledge gaps regarding the specific mechanisms.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARLSON, NICOLE S. — EMORY UNIVERSITY
- Study coordinator: CARLSON, NICOLE S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.