Understanding different types of Type 2 diabetes
Subtyping COre for Research on the Etiology of Type 2 Diabetes (SCORE-T2D)
This project uses clinical, genetic, behavioral, and social data from diverse U.S. adults with Type 2 diabetes to find meaningful subgroups so care can be more personalized.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11172602 on NIH RePORTER |
What this research studies
From a patient's perspective, researchers will combine medical records, lab tests, genetics, behavior, and social-environment information to look for distinct patterns among people with Type 2 diabetes. They will apply modern clustering and algorithmic methods designed to handle mixed types of data and to reflect U.S. racial, ethnic, and socioeconomic diversity. The effort is organized as a centralized "subtyping core" that supports multiple studies by sharing methods, tools, and harmonized data. The goal is to improve how clinicians identify who may benefit from specific prevention or treatment approaches.
Who could benefit from this research
Good fit: Adults with Type 2 diabetes, especially those from diverse racial/ethnic and socioeconomic backgrounds who can share clinical data and information about behavior and social factors, would be ideal candidates.
Not a fit: People without Type 2 diabetes, those with only Type 1 diabetes, or individuals not willing to provide clinical or social data are unlikely to get direct benefits from participating.
Why it matters
Potential benefit: If successful, this could help match people with Type 2 diabetes to treatments and prevention strategies that better fit their individual disease biology and life context.
How similar studies have performed: Prior work in large European registries has identified diabetes subgroups with different risks and treatment responses, but applying these approaches to diverse U.S. populations with broader social data is newer.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Kechris-Mays, Katherina — University of Colorado Denver
- Study coordinator: Kechris-Mays, Katherina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.