Understanding Different Types of POTS
Official title: Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
Funded at Ut Southwestern Medical Center · NIH-11117154 · Data updated 2026-11-12
This project aims to understand the different forms of Postural Orthostatic Tachycardia Syndrome (POTS) by looking closely at a large group of patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,370,048 |
| NIH project number | 5R01HL166272-03 |
| Project ID | NIH-11117154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this work are individuals diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) who are interested in contributing to a comprehensive understanding of their condition.
✕Less likely to help
Patients who do not have POTS or are not interested in participating in detailed diagnostic assessments may not directly benefit from this particular research opportunity.
What this research studies
We know that not all patients with POTS experience the same symptoms or respond to treatments in the same way. This project will carefully examine various aspects of POTS in a diverse group of individuals, including their symptoms, blood test results, heart structure, and how their muscles respond to exercise. By doing this, we hope to identify distinct types of POTS and learn how they are related. This deeper understanding will help doctors provide more personalized care and guide future efforts to find better treatments.
Why it matters
Potential benefit: If successful, this work could lead to more personalized and effective treatments for patients with POTS by helping doctors understand individual differences in the condition.
How similar studies have gone: While exercise training has shown benefit for some POTS patients, this project is novel in its comprehensive approach to defining the full picture of different POTS subtypes.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Vernino, Steven a — Ut Southwestern Medical Center
- Study coordinator: Vernino, Steven a
Related research
Other NIH-funded projects on the same topics.
-
Map heart tissue to guide VT ablation with AI help
A patient-oriented project aims to use AI-based mapping to better identify abnormal heart tissue responsible for ventricular tachycardia and guide safer, faster ablation.
-
Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
-
Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
-
Novel gene therapy tools to prevent dangerous heart rhythms
A small grant supports testing gene-therapy methods to stop ventricular tachycardia after a heart attack, with the goal of helping people at risk of sudden heart rhythm problems.
-
Understanding different types of POTS to tailor treatments
A research project is studying why people with POTS have different symptoms and how to personalize exercise-based treatment.
-
GIP and blood pooling in the gut: a potential driver of POTS symptoms
This NIH grant studies how a glucose-driven hormone affects blood flow and heart rate in adults with Postural Tachycardia Syndrome to explain why meals can worsen symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.