Understanding different types of Postural Orthostatic Tachycardia Syndrome (POTS)
Official title: Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
Funded at Ut Southwestern Medical Center · NIH-10920471 · Data updated 2026-11-12
This study is looking at different types of Postural Orthostatic Tachycardia Syndrome (POTS) to better understand the condition and find ways to improve treatment for people living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,281,984 |
| NIH project number | 5R01HL166272-02 |
| Project ID | NIH-10920471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Postural Orthostatic Tachycardia Syndrome, particularly those experiencing varying symptoms and responses to treatment.
✕Less likely to help
Patients who do not have POTS or those with other unrelated chronic conditions may not benefit from this research.
What this research studies
This research investigates Postural Orthostatic Tachycardia Syndrome (POTS), a chronic condition that causes debilitating symptoms. It aims to identify and characterize the various subtypes of POTS by conducting thorough assessments, including symptom evaluations, blood tests, and heart structure analyses, alongside examining muscle responses to exercise. By studying a diverse group of patients, the research seeks to provide insights into the underlying causes of POTS and improve treatment strategies tailored to individual patient needs.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with POTS.
How similar studies have gone: Previous research has shown promise in understanding POTS through similar multimodal approaches, indicating potential for success in this study.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Vernino, Steven a — Ut Southwestern Medical Center
- Study coordinator: Vernino, Steven a
Related research
Other NIH-funded projects on the same topics.
-
Map heart tissue to guide VT ablation with AI help
A patient-oriented project aims to use AI-based mapping to better identify abnormal heart tissue responsible for ventricular tachycardia and guide safer, faster ablation.
-
Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
-
Venous ethanol ablation to treat ischemic VT (VE-VT)
A new treatment approach uses ethanol delivered through heart veins to help stop dangerous heart rhythms in patients with previous heart damage.
-
Novel gene therapy tools to prevent dangerous heart rhythms
A small grant supports testing gene-therapy methods to stop ventricular tachycardia after a heart attack, with the goal of helping people at risk of sudden heart rhythm problems.
-
Understanding different types of POTS to tailor treatments
A research project is studying why people with POTS have different symptoms and how to personalize exercise-based treatment.
-
GIP and blood pooling in the gut: a potential driver of POTS symptoms
This NIH grant studies how a glucose-driven hormone affects blood flow and heart rate in adults with Postural Tachycardia Syndrome to explain why meals can worsen symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.