Understanding different types of pediatric type 2 diabetes using clinical and genetic methods
Pathophysiological sub-typing of pediatric type 2 diabetes based on clinical and genetic clustering methods
This study is looking at how to better understand and treat type 2 diabetes in kids, especially those from diverse backgrounds, by using advanced technology to find different types of the condition that might need different treatments, so that doctors can provide more personalized care for young patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10993663 on NIH RePORTER |
What this research studies
This research investigates how pediatric type 2 diabetes (T2D) can be categorized based on clinical and genetic factors, particularly focusing on youth of color. By utilizing machine learning techniques, the study aims to identify distinct subtypes of T2D that may respond differently to treatments like metformin. The goal is to develop more effective, personalized treatment strategies for young patients, addressing the urgent need for tailored therapies in this population. Participants will be evaluated using routinely measured clinical variables to enhance the relevance of findings to everyday clinical practice.
Who could benefit from this research
Good fit: Ideal candidates for this research are youth aged 12-20 years diagnosed with type 2 diabetes, particularly those from diverse racial and ethnic backgrounds.
Not a fit: Patients who are not diagnosed with type 2 diabetes or those outside the age range of 12-20 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children and adolescents with type 2 diabetes.
How similar studies have performed: Previous research has successfully utilized similar clustering approaches in adults, but this specific application in youth is novel and untested.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Srinivasan, Shylaja — University of California, San Francisco
- Study coordinator: Srinivasan, Shylaja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.