Understanding different types of pediatric type 2 diabetes using clinical and genetic methods
Official title: Pathophysiological sub-typing of pediatric type 2 diabetes based on clinical and genetic clustering methods
Funded at University of California, San Francisco · NIH-10993663 · Data updated 2026-11-12
This study is looking at how to better understand and treat type 2 diabetes in kids, especially those from diverse backgrounds, by using advanced technology to find different types of the condition that might need different treatments, so that doctors can provide more personalized care for young patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $121,125 |
| NIH project number | 5R03DK138213-02 |
| Project ID | NIH-10993663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are youth aged 12-20 years diagnosed with type 2 diabetes, particularly those from diverse racial and ethnic backgrounds.
✕Less likely to help
Patients who are not diagnosed with type 2 diabetes or those outside the age range of 12-20 years may not benefit from this research.
What this research studies
This research investigates how pediatric type 2 diabetes (T2D) can be categorized based on clinical and genetic factors, particularly focusing on youth of color. By utilizing machine learning techniques, the study aims to identify distinct subtypes of T2D that may respond differently to treatments like metformin. The goal is to develop more effective, personalized treatment strategies for young patients, addressing the urgent need for tailored therapies in this population. Participants will be evaluated using routinely measured clinical variables to enhance the relevance of findings to everyday clinical practice.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children and adolescents with type 2 diabetes.
How similar studies have gone: Previous research has successfully utilized similar clustering approaches in adults, but this specific application in youth is novel and untested.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Srinivasan, Shylaja — University of California, San Francisco
- Study coordinator: Srinivasan, Shylaja
Related research
Other NIH-funded projects on the same topics.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
-
Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
-
Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
-
Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
-
Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.