Understanding different types of immune cells in rheumatoid arthritis
Macrophage Heterogeneity in Rheumatoid Arthritis
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11043239
This study is looking at different types of immune cells in the joints of people with rheumatoid arthritis to find new ways to improve treatments and help you feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11043239 on ClinicalTrials.gov |
What this research studies
This research investigates the various subpopulations of macrophages, a type of immune cell, that exist in the joints of individuals with rheumatoid arthritis (RA). By examining how these macrophages function in both healthy and inflamed joints, the study aims to identify specific targets for potential therapies that could improve treatment outcomes for RA patients. The approach involves advanced techniques to analyze the genetic and environmental factors that influence macrophage behavior in the context of arthritis. This could lead to more effective and tailored treatments for those suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who are experiencing joint inflammation and damage.
Not a fit: Patients with other forms of arthritis or those without active inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that specifically target harmful macrophage subpopulations, potentially reducing inflammation and joint damage in rheumatoid arthritis patients.
How similar studies have performed: Previous research has shown promise in targeting specific immune cell populations for therapeutic benefit, suggesting that this approach could yield significant advancements in treating rheumatoid arthritis.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PERLMAN, HARRIS R — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: PERLMAN, HARRIS R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.