Understanding different types of heart failure to improve treatment options
Official title: HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targets
Funded at Northwestern University at Chicago · NIH-11167161 · Data updated 2026-11-12
This study is looking at different types of heart failure with preserved ejection fraction (HFpEF) to better understand the condition and find more effective treatments, and it's inviting patients to participate by sharing their health information and experiences.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $303,614 |
| NIH project number | 3U54HL160273-04S1 |
| Project ID | NIH-11167161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction (HFpEF).
✕Less likely to help
Patients with heart failure with reduced ejection fraction (HFrEF) may not benefit from this research as it specifically targets HFpEF.
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a complex condition that affects many patients but lacks effective treatment options. The project aims to classify HFpEF into distinct subtypes by conducting in-depth assessments of patients and analyzing electronic health records from multiple sites. By identifying the specific mechanisms and characteristics of each subtype, the research seeks to uncover potential therapeutic targets that could lead to more personalized and effective treatments for patients. Participants will undergo comprehensive evaluations and contribute to a longitudinal registry that tracks their health over time.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies tailored to the specific needs of patients with different subtypes of heart failure.
How similar studies have gone: Previous research has shown promise in classifying heart failure subtypes, but this approach aims to further refine understanding and treatment options, making it a novel endeavor.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Shah, Sanjiv J — Northwestern University at Chicago
- Study coordinator: Shah, Sanjiv J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.