Understanding different types of eye pain using brain imaging and nerve analysis
Official title: Differentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain Imaging
Funded at Boston Children's Hospital · NIH-10906804 · Data updated 2026-11-12
This study is looking into why some people with dry eye and Sjogren's syndrome experience chronic eye pain, using special imaging and tests to better understand the differences in their nervous system, so we can improve how we diagnose and treat their pain.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $958,830 |
| NIH project number | 5U01EY034686-03 |
| Project ID | NIH-10906804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults experiencing chronic ocular pain, particularly those with dry eye or related conditions.
✕Less likely to help
Patients with acute ocular pain or those without chronic symptoms may not benefit from this research.
What this research studies
This research investigates the underlying causes of chronic ocular pain, particularly in patients with dry eye and conditions like Sjogren's syndrome. By using advanced imaging techniques and sensory testing, the study aims to identify structural and functional differences in the nervous system that contribute to inflammatory and neuropathic pain. Participants will undergo various assessments, including neuroimaging and nerve microscopy, to help differentiate between types of pain and improve diagnosis and treatment options. The goal is to provide clearer insights into how these pain conditions affect patients and to develop better management strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients suffering from chronic ocular pain.
How similar studies have gone: Previous research has shown promise in using neuroimaging to understand pain mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Moulton, Eric Alan — Boston Children's Hospital
- Study coordinator: Moulton, Eric Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.