Understanding different types of dopamine neurons involved in addiction
Official title: Molecular and Functional Characterization of Transcriptionally Defined Subpopulations of VTA Dopamine Neurons
Funded at University of Alabama at Birmingham · NIH-11070542 · Data updated 2026-11-12
This study is looking at different types of brain cells that are linked to addiction, hoping to find clues that could help us understand why some people struggle with substance use, which could lead to better treatments for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | May 1, 2025 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,856 |
| NIH project number | 1F30DA062497-01 |
| Project ID | NIH-11070542 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with substance use disorders or those at risk of developing such conditions.
✕Less likely to help
Patients who do not have a history of substance use or are not affected by addiction-related issues may not benefit from this research.
What this research studies
This research investigates the distinct subpopulations of dopamine neurons in the brain that are involved in substance use disorders. By using advanced techniques like single nucleus RNA sequencing, the study aims to identify specific markers for these neurons, which could help in understanding their roles in addiction. The research focuses on how these neurons communicate and their implications for drug-seeking behaviors, particularly in the context of the rising rates of drug overdoses. Patients may benefit from insights gained about the neurobiological mechanisms underlying addiction.
Why it matters
Potential benefit: If successful, this research could lead to more targeted treatments for substance use disorders, improving recovery outcomes for patients.
How similar studies have gone: Other research has shown promise in understanding the roles of different neuron types in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Fitzgerald, Natalie Dalton — University of Alabama at Birmingham
- Study coordinator: Fitzgerald, Natalie Dalton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.