Understanding different types of diabetes and their progression over time
Official title: Longitudinal omics-based trajectories of type 2 diabetes subtypes: the T2D Heterogeneity Consortium
Funded at Massachusetts General Hospital · NIH-10974745 · Data updated 2026-11-12
This study is looking at different types of type 2 diabetes to find better ways to diagnose and treat it, so patients can get more personalized care that fits their unique needs.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $823,473 |
| NIH project number | 1U01DK140761-01 |
| Project ID | NIH-10974745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with type 2 diabetes or those at risk of developing the condition.
✕Less likely to help
Patients with type 1 diabetes or those who do not have diabetes or prediabetes may not benefit from this research.
What this research studies
This research investigates the various subtypes of type 2 diabetes by analyzing clinical and multi-omic data to improve diagnosis and treatment. It aims to redefine how diabetes and prediabetes are classified, moving beyond traditional glucose and HbA1c measures. By integrating diverse data types, the study seeks to develop predictive models that can track disease progression and personalize treatment strategies for better patient outcomes. Patients may benefit from more accurate diagnoses and tailored therapies that address their specific diabetes subtype.
Why it matters
Potential benefit: If successful, this research could lead to more precise diagnoses and personalized treatment plans for individuals with type 2 diabetes.
How similar studies have gone: Previous research has shown promise in classifying diabetes subtypes using multi-omic approaches, indicating potential for success in this novel investigation.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Manning, Alisa Knodle — Massachusetts General Hospital
- Study coordinator: Manning, Alisa Knodle
Related research
Other NIH-funded projects on the same topics.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
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-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.