Understanding different types of antibodies related to pregnancy complications
Differentiating clinical characteristics between two subtypes of antiphosphatidylethanolamine
['FUNDING_R21'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10654055
This study is looking at two types of antibodies related to antiphospholipid syndrome, which can cause problems during pregnancy, to see how they differ and how they might help doctors provide better care for expectant mothers facing these challenges.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10654055 on ClinicalTrials.gov |
What this research studies
This research investigates two distinct subtypes of antiphosphatidylethanolamine (aPE) autoantibodies that are linked to antiphospholipid syndrome (APS), a condition that can cause complications during pregnancy. By analyzing clinical data retrospectively, the study aims to determine how these subtypes differ in their clinical characteristics and associations with APS symptoms. This could lead to improved diagnostic criteria and better patient care for those affected by pregnancy-related complications linked to these antibodies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals or those planning to become pregnant who have been diagnosed with antiphospholipid syndrome or have a history of pregnancy complications.
Not a fit: Patients without a diagnosis of antiphospholipid syndrome or those not experiencing pregnancy-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the understanding and management of pregnancy complications associated with antiphospholipid syndrome.
How similar studies have performed: Previous research has shown promise in differentiating antibody subtypes in autoimmune conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, MING — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: ZHAO, MING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.