Understanding different types of alpha-synuclein in dementia
Shedding light on functional heterogeneity of dementia-related alpha-synuclein strains
This study is looking at how different types of a protein linked to Lewy bodies dementia affect brain function and how the disease progresses, using special imaging in live mice to help us understand more about cognitive decline and improve treatments for dementia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10447375 on NIH RePORTER |
What this research studies
This research investigates how different strains of alpha-synuclein, a protein associated with Lewy bodies dementia, affect brain function and disease progression. By using advanced imaging techniques in live mice, the study aims to observe how these strains interact with brain cells over time. The goal is to uncover the mechanisms behind the varying effects of these strains on cognitive decline, which could lead to better understanding and treatment of dementia-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy bodies dementia or Parkinson's disease with cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to alpha-synuclein pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with Lewy bodies dementia and related cognitive impairments.
How similar studies have performed: Previous research has shown promising results in understanding protein strains in neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Liang, Yajie — University of Maryland Baltimore
- Study coordinator: Liang, Yajie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.