Understanding different types of adult-onset diabetes and their causes
Official title: Subtyping COre for Research on the Etiology of Type 2 Diabetes (SCORE-T2D)
Funded at University of Colorado Denver · NIH-10974202 · Data updated 2026-11-12
This study is looking at the different types of type 2 diabetes to find out what makes each person’s experience unique, so we can create better ways to prevent and treat the condition, and we need people with type 2 diabetes to share their health and lifestyle information to help us understand it better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,352,478 |
| NIH project number | 1U01DK140738-01 |
| Project ID | NIH-10974202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with type 2 diabetes, particularly those from diverse racial, ethnic, and socioeconomic backgrounds.
✕Less likely to help
Patients with type 1 diabetes or those who do not have a diagnosis of type 2 diabetes may not benefit from this research.
What this research studies
This research investigates the various subtypes of type 2 diabetes (T2D) to better understand the different factors that contribute to the disease's development and progression. By using advanced algorithms and analyzing diverse data from clinical, behavioral, and environmental sources, the study aims to identify distinct groups of individuals with T2D based on their unique characteristics. This approach seeks to improve prevention and treatment strategies tailored to individual needs, particularly focusing on the diverse U.S. population. Participants will provide data on their health, lifestyle, and social factors to help create a more comprehensive understanding of T2D.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for individuals with type 2 diabetes.
How similar studies have gone: Previous research has shown promise in using clustering algorithms to identify diabetes subtypes, but this study aims to expand on those findings with a focus on U.S. population diversity.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Kechris-Mays, Katherina — University of Colorado Denver
- Study coordinator: Kechris-Mays, Katherina
Related research
Other NIH-funded projects on the same topics.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.