Understanding different states of cancer cells to improve treatment
Identification and characterization of cancer cell states by novel computational and experimental technologies - Resubmission - 1
['FUNDING_U01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11080767
This study is looking at the different types of cancer cells in tumors to see how their unique traits affect how they respond to treatment, using advanced technology and zebrafish to help understand these differences better.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11080767 on ClinicalTrials.gov |
What this research studies
This research investigates the various states of cancer cells within tumors, focusing on their genetic and transcriptional differences. By utilizing advanced technologies like single-cell RNA sequencing and a zebrafish model, the project aims to identify and characterize these distinct cell states. This approach will help researchers understand how these states contribute to drug resistance and cancer progression. The study will involve both computational methods and experimental validation using human samples and engineered zebrafish to observe cancer cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who are experiencing treatment resistance or progression.
Not a fit: Patients with early-stage cancer who are responding well to standard treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies by targeting specific cell states that contribute to treatment resistance.
How similar studies have performed: Other research has shown promise in understanding cancer cell heterogeneity, but this approach using zebrafish models and advanced computational methods is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANAI, ITAI — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: YANAI, ITAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Atlas of Cancer Mortality in the United States, Cancer Biology, cancer cell, Cancer Maps