Understanding Different Fibroblast Cells in Pancreatic Cancer
Fibroblast Heterogeneity in Pancreatic Cancer
This project aims to understand the different types of support cells in pancreatic tumors to find new ways to treat pancreatic cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11141877 on NIH RePORTER |
What this research studies
Pancreatic cancer often has a dense network of support cells, called fibroblasts, which makes treatment difficult. We are learning about the different kinds of fibroblasts within these tumors to see which ones help the cancer grow and which ones might not. By identifying these specific types, we hope to develop smarter treatments that target only the harmful cells, leaving the helpful ones alone. This could lead to more effective therapies for patients with pancreatic cancer.
Who could benefit from this research
Good fit: This foundational research focuses on understanding cancer biology and does not currently involve patient recruitment for direct participation.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not benefit from this early-stage biological research.
Why it matters
Potential benefit: If successful, this work could lead to new, more effective treatments for pancreatic cancer by targeting specific cells that help the tumor grow.
How similar studies have performed: Previous attempts to broadly target these support cells have had mixed results, highlighting the need for this more detailed and specific approach.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Tuveson, David a — Cold Spring Harbor Laboratory
- Study coordinator: Tuveson, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.