Understanding different cell types in tumors using advanced sequencing techniques
Multiscale Resolution and Deep Network Approaches for Deconvolving Different Cell Types in Bulk Tumor using Single-cell Sequencing Data (scDEC)
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10685960
This study is looking at the different types of cells in glioblastoma tumors to better understand how they behave and respond to treatments, which could help improve cancer care for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10685960 on ClinicalTrials.gov |
What this research studies
This research investigates the complex cellular makeup of tumors, particularly glioblastomas, by utilizing advanced single-cell RNA sequencing techniques. It aims to identify and quantify various malignant and non-malignant cell types within tumors, which can provide insights into tumor behavior, treatment responses, and patient outcomes. By employing a novel deep learning approach, the study will analyze bulk tumor samples to reveal the presence of different immune cell types and their associations with disease characteristics. This could lead to improved strategies for cancer treatment and management.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma or other types of malignant tumors who are undergoing treatment.
Not a fit: Patients with non-malignant tumors or those not diagnosed with cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance personalized treatment approaches for cancer patients by providing detailed insights into tumor composition and behavior.
How similar studies have performed: Previous research has shown promise in using single-cell sequencing techniques to analyze tumor heterogeneity, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, XIAOBO — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: ZHOU, XIAOBO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Disease, Disorder