Understanding different causes of prostate cancer based on tumor types
Official title: Etiologic Heterogeneity Between Molecular Subtypes of Prostate Cancer
Funded at Massachusetts General Hospital · NIH-10892857 · Data updated 2026-11-12
This study is looking at how different types of prostate cancer might have unique risk factors, especially focusing on a large group of men, including many African-American participants, to help us better understand the disease and improve prevention strategies.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $654,340 |
| NIH project number | 5R37CA275914-02 |
| Project ID | NIH-10892857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include men diagnosed with prostate cancer, particularly those who are African-American or have a family history of the disease.
✕Less likely to help
Patients with prostate cancer who do not have identifiable molecular subtypes or those with advanced metastatic disease may not benefit from this research.
What this research studies
This research investigates how risk factors for prostate cancer vary depending on the molecular subtype of the tumor. By analyzing data from over 107,000 men, including a significant number of African-American participants, the project aims to identify specific risk factors associated with different tumor types. The study utilizes advanced pathology techniques to profile prostate tumors and assess their genetic characteristics. This approach will help lay the groundwork for future prevention strategies and deeper understanding of prostate cancer mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more targeted prevention strategies for prostate cancer, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in identifying risk factors associated with specific molecular subtypes of prostate cancer, indicating that this approach has potential for success.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Stopsack, Konrad Hermann — Massachusetts General Hospital
- Study coordinator: Stopsack, Konrad Hermann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.