Understanding different causes and effects of sleep apnea
Sleep Apnea Endophenotypes: One Size Does Not Fit All
This study is looking at how different factors in obstructive sleep apnea (OSA) affect symptoms and health, so we can better personalize treatments for each patient and help them stick to therapies like CPAP, ultimately improving their overall health and well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11124776 on NIH RePORTER |
What this research studies
This research investigates the various underlying mechanisms of obstructive sleep apnea (OSA) and how they lead to different symptoms and health consequences in patients. By measuring factors such as airway collapsibility and arousal thresholds, the study aims to identify distinct endotypes of OSA. This understanding could help tailor treatments to individual patients, improving adherence to therapies like continuous positive airway pressure (PAP) and predicting which symptoms may improve with treatment. The goal is to enhance patient outcomes by personalizing therapy based on the specific characteristics of their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with obstructive sleep apnea, particularly those experiencing varying symptoms and treatment responses.
Not a fit: Patients with sleep apnea who do not have identifiable endotypes or those who are not seeking treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for sleep apnea, improving patient adherence and health outcomes.
How similar studies have performed: Other research has shown promise in understanding sleep apnea through personalized approaches, indicating that this study builds on existing knowledge rather than being entirely novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Malhotra, Atul — University of California, San Diego
- Study coordinator: Malhotra, Atul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.