Understanding differences between clinical trial participants and real-world patients
Official title: Characterizing Population Differences between Clinical Trial and Real World Populations
Funded at University of Chicago · NIH-11098549 · Data updated 2026-11-12
This study looks at how patients in clinical trials are different from those in everyday life to better understand how treatments work, so that everyone can benefit from more accurate information about their care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 15, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00NS114850-05 |
| Project ID | NIH-11098549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have participated in clinical trials or those receiving treatments in real-world settings for conditions studied in the trials.
✕Less likely to help
Patients who are not involved in clinical trials or do not receive treatments related to the conditions being studied may not benefit from this research.
What this research studies
This research investigates how clinical trial populations differ from real-world patients to improve treatment understanding. It uses advanced statistical methods to analyze data from both clinical trials and real-world settings, aiming to identify factors that influence treatment outcomes. By comparing individual-level data from trials with observational data, the research seeks to enhance the reliability of treatment estimates across diverse patient populations. This could help in understanding how therapies work outside of controlled trial environments.
Why it matters
Potential benefit: If successful, this research could lead to more accurate treatment recommendations for patients based on real-world evidence.
How similar studies have gone: Other research has shown promise in using observational data to simulate clinical trial outcomes, indicating that this approach has potential for success.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Beaulieu-Jones, Brett K — University of Chicago
- Study coordinator: Beaulieu-Jones, Brett K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.