Understanding diabetes risk in teenagers
Official title: Assessing Diabetes Risk Origins in Teens (ADROIT)
Funded at Children's Hosp of Philadelphia · NIH-11045720 · Data updated 2026-11-12
This study is looking at what causes type 2 diabetes in teens who are overweight or at risk, and it aims to find ways to help prevent diabetes by checking how their bodies respond to sugar and understanding their lifestyle habits.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 5, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $749,173 |
| NIH project number | 5U01DK135002-03 |
| Project ID | NIH-11045720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents aged 12-20 who are overweight and have been identified as having prediabetes.
✕Less likely to help
Patients who are not adolescents or do not have risk factors for diabetes, such as those with a healthy weight and no family history of diabetes, may not benefit from this research.
What this research studies
This research investigates the factors that contribute to the development of type 2 diabetes in adolescents, particularly those who are overweight or have prediabetes. By conducting a multi-center study, the team will analyze how various biological and lifestyle factors affect insulin resistance and diabetes progression over time. Participants will undergo a series of oral glucose tolerance tests to monitor their insulin response and identify those at highest risk for developing diabetes. The goal is to create targeted interventions that can help prevent the onset of diabetes in at-risk youth.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for type 2 diabetes in adolescents, potentially reducing the incidence of this serious condition.
How similar studies have gone: Previous research has shown promise in identifying risk factors for diabetes in youth, but this study aims to refine those approaches and provide more targeted interventions.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Katz, Lorraine E Levitt — Children's Hosp of Philadelphia
- Study coordinator: Katz, Lorraine E Levitt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.