Understanding diabetes linked to diseases of the pancreas
Official title: Investigating mechanisms underlying diabetes associated with exocrine pancreas diseases
Funded at Stanford University · NIH-10978799 · Data updated 2026-11-12
This study is looking at how problems with the pancreas, like chronic pancreatitis and pancreatic cancer, can lead to a special kind of diabetes called type 3c diabetes, and it aims to understand the underlying causes by examining cells from patients to see how inflammation affects insulin production.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 7, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $577,694 |
| NIH project number | 1R01DK138632-01A1 |
| Project ID | NIH-10978799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with chronic pancreatitis or pancreatic ductal adenocarcinoma who may be experiencing or at risk for type 3c diabetes.
✕Less likely to help
Patients without any pancreatic diseases or those with type 1 or type 2 diabetes unrelated to pancreatic conditions may not benefit from this research.
What this research studies
This research investigates how diseases of the exocrine pancreas, such as chronic pancreatitis and pancreatic cancer, can lead to a specific type of diabetes known as type 3c diabetes mellitus. The study focuses on understanding the cellular and genetic mechanisms that contribute to this condition by examining pancreatic islet cells from affected patients. Researchers will analyze gene expression and signaling pathways to uncover how inflammation and other factors disrupt normal insulin regulation. By using advanced imaging techniques and in vitro studies, the research aims to clarify the relationship between pancreatic diseases and diabetes development.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of diabetes that arises from pancreatic diseases, potentially improving treatment options for affected patients.
How similar studies have gone: While the specific mechanisms of type 3c diabetes are not fully understood, previous research has shown promising results in exploring the links between pancreatic diseases and diabetes, indicating that this area of study has potential for significant findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Kim, Seung K — Stanford University
- Study coordinator: Kim, Seung K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.