Understanding depression recurrence and cognitive effects in older adults
1/3-Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-life Depression (Rembrandt)
This study is looking at how changes in the brain might cause older adults to experience depression again, with the goal of finding ways to help prevent future episodes and improve their overall well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10749945 on NIH RePORTER |
What this research studies
This research investigates the factors that contribute to the recurrence of major depressive episodes in older adults, particularly focusing on the neurobiological aspects that may trigger these episodes. It aims to understand how disruptions in brain networks related to mood and cognition can lead to increased risks of depression recurrence and cognitive decline. By studying older adults who have experienced depression, the research seeks to identify patterns and predictors that could help in managing and preventing future episodes. The approach includes analyzing brain function and stability in response to stressors, which may provide insights into better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced major depressive episodes and are currently in remission but may be at risk for recurrence.
Not a fit: Patients who are younger or have not experienced major depressive episodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for depression in older adults, potentially reducing recurrence rates and cognitive decline.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological factors associated with depression recurrence, indicating that this approach has potential for significant insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Taylor, Warren D — Vanderbilt University Medical Center
- Study coordinator: Taylor, Warren D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.