Understanding Dental and Bone Problems in X-linked Hypophosphatemia
Identifying Novel Mechanisms for Dentoalveolar Mineralization Defects in X-linked Hypophosphatemia
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11113979
This work aims to discover new reasons why people with X-linked hypophosphatemia (XLH) experience dental and bone mineralization issues, hoping to find better ways to help.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11113979 on ClinicalTrials.gov |
What this research studies
People with X-linked hypophosphatemia (XLH) often have problems with their teeth and bones not forming correctly, which current treatments don't fully fix. This project explores the underlying causes of these specific dental and bone defects, looking beyond the main known issues in XLH. We want to understand how certain body chemicals and processes contribute to these problems. By uncovering these new mechanisms, we hope to pave the way for more effective and targeted treatments that can truly improve oral health and quality of life for individuals with XLH.
Who could benefit from this research
Good fit: This foundational work is for individuals living with X-linked hypophosphatemia (XLH) who experience persistent dental and bone mineralization issues.
Not a fit: Patients without X-linked hypophosphatemia or those whose symptoms are fully managed by current therapies may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically address the dental and bone mineralization defects in X-linked hypophosphatemia, improving oral health and overall well-being.
How similar studies have performed: Current treatments for XLH, including a new antibody therapy, have shown limited success in fully resolving these specific dental and bone defects, indicating this approach explores novel, unaddressed mechanisms.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOSTER, BRIAN LEE — OHIO STATE UNIVERSITY
- Study coordinator: FOSTER, BRIAN LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.