Understanding decision-making issues in borderline personality disorder

Neurocomputational mechanisms of impaired social decision-making in borderline personality

NIH-funded research Univ of North Carolina Chapel Hill · NIH-10608199

This study looks at how people with borderline personality disorder (BPD) make choices, especially when they face negative social situations, to better understand how their emotions can affect their decisions and help find ways to improve their decision-making and emotional control.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of North Carolina Chapel Hill NIH-funded
Lab location1 site (Chapel Hill, United States)
Project IDNIH-10608199 on NIH RePORTER

What this research studies

This research investigates how individuals with borderline personality disorder (BPD) make decisions, particularly in response to negative social interactions. It focuses on the brain's decision-making processes, specifically how emotional cues can disrupt goal-directed behavior. By studying the cingulo-opercular network in the brain, the research aims to uncover the mechanisms that lead to maladaptive decision-making in adolescents and adults with BPD. The findings could help in developing targeted interventions to improve decision-making and emotional regulation in affected individuals.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents and adults diagnosed with borderline personality disorder who experience difficulties in social decision-making.

Not a fit: Patients without a diagnosis of borderline personality disorder or those who do not exhibit decision-making impairments related to social interactions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better treatment strategies for individuals with borderline personality disorder, improving their decision-making and emotional responses.

How similar studies have performed: Previous research has shown promising results in understanding decision-making processes in mental health disorders, suggesting that this approach could yield valuable insights.

Where this research is happening

Chapel Hill, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.