Understanding decision-making in Parkinson's disease using brain stimulation
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulation
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11035120
This study is looking at how brain signals affect decision-making in people with Parkinson's disease, especially when it comes to motivation, and aims to find ways to improve their choices and quality of life using a special brain stimulation technique.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11035120 on ClinicalTrials.gov |
What this research studies
This research investigates how brain signals influence decision-making in individuals with Parkinson's disease, particularly focusing on motivation deficits that affect their quality of life. By using closed-loop deep brain stimulation, the study aims to identify specific neural mechanisms that control goal-directed choices. The researchers will analyze brain activity patterns, particularly in the basal ganglia, to understand how these signals can be manipulated to improve decision-making. The ultimate goal is to develop new therapies that can enhance motivation and decision-making abilities in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motivation deficits.
Not a fit: Patients with Parkinson's disease who do not exhibit motivation deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve motivation and decision-making in patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promise in using brain stimulation techniques to influence decision-making, suggesting that this approach may yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOY, COLIN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: HOY, COLIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Behavior Disorders, behavioral disorder