Understanding Daily Rhythms in Kidney Cancer
CIRCADIAN REGULATION OF HIF2alpha IN ccRCC
This research explores how our body's natural daily rhythms might influence clear cell renal cell carcinoma, a type of kidney cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11090362 on NIH RePORTER |
What this research studies
Our bodies have internal clocks, called circadian rhythms, that guide daily functions like sleep and wakefulness. This project looks at how disruptions to these rhythms, similar to what happens with shift work or frequent travel, could increase the risk of certain cancers. We are focusing on a specific protein called HIF2alpha, which often becomes overactive in clear cell renal cell carcinoma. The goal is to understand how our internal clock components, like BMAL1 and CRY proteins, control HIF2alpha activity and how this affects cancer cell growth.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but aims to benefit individuals with clear cell renal cell carcinoma in the future.
Not a fit: Patients without clear cell renal cell carcinoma would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat clear cell renal cell carcinoma by targeting the body's internal clock or related pathways.
How similar studies have performed: Previous work has shown that circadian clock components regulate HIF2alpha activity, providing a basis for this deeper investigation.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Lamia, Katja a — Scripps Research Institute, the
- Study coordinator: Lamia, Katja a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.