Understanding daily rhythms in Alzheimer's disease
Circadian Organization and Disorder in Alzheimer's Disease
This study is looking at how changes in daily habits and body rhythms might influence the progression of Alzheimer's disease, with the hope of finding new ways to help patients and their caregivers feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10892234 on NIH RePORTER |
What this research studies
This research investigates how altered daily rhythms in physiology and behavior affect Alzheimer's disease (AD) progression and development. By analyzing brain samples, the study aims to identify molecular rhythms that may contribute to the symptoms of AD. The researchers have developed a machine-learning tool called CYCLOPS to uncover these rhythms from unordered biopsy samples, which could lead to new therapeutic approaches. The ultimate goal is to improve care for patients and support their caregivers by understanding these daily patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who may experience altered daily rhythms.
Not a fit: Patients with early-stage cognitive impairment or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the quality of life for patients with Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding circadian rhythms in various conditions, suggesting potential for success in this novel approach to Alzheimer's disease.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Anafi, Ron C. — University of Pennsylvania
- Study coordinator: Anafi, Ron C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.